Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ 1–42
Joint Authors
Liu, Jiangang
Liu, Meixia
Cao, Yu
Jia, Xingxing
Wei, Yun
Li, Hao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Huannao Yicong Decoction (HYD, 还脑益聪方) has been shown to improve the learning and memory capabilities of Alzheimer’s disease (AD) subjects.
However, the underlying mechanism remains to be determined.
Methods.
Sixty Sprague-Dawley rats were divided equally and randomly into five different groups including control, positive control, and HYD granules of low dose, medium dose, and high dose by daily gavage.
The sham-treated rats were also given the same volume of sterile water by gavage.
Twelve SD rats were treated with the same amount of physiological saline.
Twelve weeks later, learning and memory capabilities, Aβ content of the right brain and the expression of glycogen synthase kinase-3β (GSK-3β), total tau protein kinase (TTBK1), and cyclin-dependent kinase-5 (CDK-5) were tested.
Results.
Our results showed that high dose HYD treatment significantly improved the learning and memory capability of the AD rats and decreased the expression of TTBK1, GSK-3β, and CDK-5 in the hippocampal CA1 region.
Conclusions.
HYD treatment for 12 weeks significantly improved spatial learning and memory and effectively inhibited Aβ deposition, likely via reducing tau protein kinase expression and thus tau hyperphosphorylation and inflammatory injury.
Taken together, these results suggest that HYD could be an effective treatment for AD.
American Psychological Association (APA)
Cao, Yu& Jia, Xingxing& Wei, Yun& Liu, Meixia& Liu, Jiangang& Li, Hao. 2016. Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ 1–42. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104302
Modern Language Association (MLA)
Cao, Yu…[et al.]. Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ 1–42. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104302
American Medical Association (AMA)
Cao, Yu& Jia, Xingxing& Wei, Yun& Liu, Meixia& Liu, Jiangang& Li, Hao. Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer’s Disease Model Rats Induced by Aβ 1–42. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104302