Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus
Joint Authors
Denzler, Karen
Moore, Jessica
Harrington, Heather
Morrill, Kira
Huynh, Trung
Jacobs, Bertram
Waters, Robert
Langland, Jeffrey
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The botanical, Astragalus membranaceus, is a therapeutic in traditional Chinese medicine.
Limited literature exists on the overall in vivo effects of A.
membranaceus on the human body.
This study evaluates the physiological responses to A.
membranaceus by measuring leukocyte, platelet, and cytokine responses as well as body temperature and blood pressure in healthy individuals after the in vivo administration of A.
membranaceus.
A dose-dependent increase in monocytes, neutrophils, and lymphocytes was measured 8–12 hours after administration and an increase in the number of circulating platelets was seen as early as 4 hours.
A dynamic change in the levels of circulating cytokines was observed, especially in interferon-γ and tumor necrosis factor-α, IL-13, IL-6, and soluble IL-2R.
Subjective symptoms reported by participants were similar to those typically experienced in viral type immune responses and included fatigue, malaise, and headache.
Systolic and diastolic blood pressure were reduced within 4 hours after administration, while body temperature mildly increased within 8 hours after administration.
In general, all responses returned to baseline values by 24 hours.
Collectively, these results support the role of A.
membranaceus in priming for a potential immune response as well as its effect on blood flow and wound healing.
American Psychological Association (APA)
Denzler, Karen& Moore, Jessica& Harrington, Heather& Morrill, Kira& Huynh, Trung& Jacobs, Bertram…[et al.]. 2016. Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104305
Modern Language Association (MLA)
Denzler, Karen…[et al.]. Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104305
American Medical Association (AMA)
Denzler, Karen& Moore, Jessica& Harrington, Heather& Morrill, Kira& Huynh, Trung& Jacobs, Bertram…[et al.]. Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104305