Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells
Joint Authors
Yan, Pan
Liu, Luming
Song, Libin
Dong, Lei
Weng, Lao I.
Wang, Peng
Hua, Yongqiang
Chen, Zhen
Gao, Song
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Qingyihuaji formula (QYHJ), confirmed efficacious in a series of clinical trials, has been applied to human pancreatic carcinoma treatment in Shanghai Cancer Center for years.
Recent evidence highlighted that pluripotent stem cells transcription factor Nanog plays a pivotal role in carcinogenesis.
However, there is little published information regarding the underlying clinical significance and mechanisms of transcription factor Nanog in pancreatic cancer.
In this study, our results indicated that Nanog is overexpressed in human pancreatic cancer stem cells and downregulated by QYHJ, which may contribute to explain the clinical effectiveness of QYHJ and provide advanced pancreatic cancer patients with a new therapeutic option, supporting our hypothesis that the degradation pathway is another mechanism by which QYHJ affects Nanog expression.
American Psychological Association (APA)
Gao, Song& Yan, Pan& Song, Libin& Dong, Lei& Weng, Lao I.& Wang, Peng…[et al.]. 2016. Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104315
Modern Language Association (MLA)
Gao, Song…[et al.]. Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104315
American Medical Association (AMA)
Gao, Song& Yan, Pan& Song, Libin& Dong, Lei& Weng, Lao I.& Wang, Peng…[et al.]. Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104315