Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function
Joint Authors
Liang, Qian-Qian
Chen, Yan
Shi, Qi
Wang, Yong-Jun
Li, Qiang
Wang, Tengteng
Xing, Lianping
Xu, Hao
Zhou, Quan
Li, Jin-long
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To investigate whether Du-Huo-Ji-Sheng-Tang (DHJST) attenuate inflammation of RA related to lymphatic drainage function in vivo, we treated eight 3-month-old TNF-Tg mice with DHJST (12 g/kg) or the same volume of physiological saline once every day for 12 weeks, and 3-month-old WT littermates were used as negative control.
After twelve weeks, we performed NIR-ICG imaging and found that DHJST increased the ICG clearance at the footpad and the pulse of efferent lymphatic vessel between popliteal lymph node and footpad.
Histology staining at ankle joints showed that DHJST decreases synovial inflammation, bone erosion, cartilage erosion, and TRAP+ osteoclast area in TNF-Tg mice.
Immunohistochemical staining by using anti-Lyve-1 and anti-podoplanin antibody showed that DHJST stimulated lymphangiogenesis in ankle joints of TNF-Tg mice.
And zebrafish study suggested that DHJST promoted the formation of lymphatic thoracic duct.
In conclusion, DHJST inhibits inflammation severity and promotes lymphangiogenesis and lymphatic drainage function of TNF-Tg mice.
American Psychological Association (APA)
Chen, Yan& Li, Jin-long& Li, Qiang& Wang, Tengteng& Xing, Lianping& Xu, Hao…[et al.]. 2016. Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104318
Modern Language Association (MLA)
Chen, Yan…[et al.]. Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104318
American Medical Association (AMA)
Chen, Yan& Li, Jin-long& Li, Qiang& Wang, Tengteng& Xing, Lianping& Xu, Hao…[et al.]. Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104318