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Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model
Joint Authors
Yu, Zhan-ge
Zhao, Jun-yun
Shen, Qian
Liu, Shou-yao
Zhang, Qing-xi
Wang, Yunting
Wang, Rongguo
Xu, Qianwei
Xiao, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To explore the effects of electroacupuncture (EA) at ST36 (EA-ST36) and at Ashi acupoints (EA-Ashi) on skeletal muscle repair.
Methods.
Seventy-five rabbits were randomly divided into five groups: normal, contusion, EA-Ashi, EA-ST36, and EA at Ashi acupoints and ST36 (EA-AS).
EA (0.4 mA, 2 Hz, 15 min) was applied after an acute gastrocnemius contusion.
The morphology of myofibers and neuromuscular junctions (NMJs) and expressions of growth differentiation factor-8 (GDF-8), acetylcholinesterase (AChE), Neuregulin 1 (NGR1), and muscle-specific kinase (MuSK) were assessed 7, 14, and 28 days after contusion.
Results.
Compared with that in contusion group, there was an increase in the following respective parameters in treatment groups: the number and diameter of myofibers, the mean staining area, and continuities of NMJs.
A comparison of EA-Ashi and EA-ST36 groups indicated that average myofiber diameter, mean staining area of NMJs, and expressions of AChE and NRG1 were higher in EA-Ashi group, whereas expression of GDF-8 decreased on day 7.
However, increases in myofiber numbers, expressions of MuSK and AChE, as well as decreases in GDF-8 expression, and the discontinuities were observed in EA-ST36 group on the 28th day.
Conclusion.
Both EA-ST36 and EA-Ashi promoted myofiber regeneration and restoration of NMJs.
EA-Ashi was more effective at earlier stages, whereas EA-ST36 played a more important role at later stages.
American Psychological Association (APA)
Yu, Zhan-ge& Wang, Rongguo& Xiao, Cheng& Zhao, Jun-yun& Shen, Qian& Liu, Shou-yao…[et al.]. 2016. Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104319
Modern Language Association (MLA)
Yu, Zhan-ge…[et al.]. Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104319
American Medical Association (AMA)
Yu, Zhan-ge& Wang, Rongguo& Xiao, Cheng& Zhao, Jun-yun& Shen, Qian& Liu, Shou-yao…[et al.]. Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104319