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Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis
Joint Authors
Wang, Huajun
Cheng, Yanmei
Shao, Decheng
Chen, Junyuan
Sang, Yuan
Gui, Tao
Luo, Simin
Li, Jieruo
Chen, Chao
Ye, Yongguang
Yang, Yong
Li, Yikai
Zha, Zhengang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Studies revealed that metabolic factors might contribute substantially to osteoarthritis (OA) pathogenesis.
There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome (MetS).
The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis.
Methods.
Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies.
Data were extracted separately by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
Results.
The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search.
The crude pooled OR is 2.24 (95% CI = 1.38–3.64).
Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study.
The pooled adjusted OR remained significant with pooled adjusted OR 1.05 (95% CI = 1.03–1.07, p<0.00001).
No publication bias was found in the present meta-analysis.
Conclusions.
The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.
American Psychological Association (APA)
Wang, Huajun& Cheng, Yanmei& Shao, Decheng& Chen, Junyuan& Sang, Yuan& Gui, Tao…[et al.]. 2016. Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104330
Modern Language Association (MLA)
Wang, Huajun…[et al.]. Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104330
American Medical Association (AMA)
Wang, Huajun& Cheng, Yanmei& Shao, Decheng& Chen, Junyuan& Sang, Yuan& Gui, Tao…[et al.]. Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104330