Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity
Joint Authors
Shao, Zhifeng
Xu, Ling
Lu, Jun
Zhang, Xiaoli
Shen, Tingting
Ma, Chao
Wu, Jun
Kong, Hualei
Tian, Jing
Zhao, Xiaodong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Traditional Chinese medicine Jinfukang (JFK) has been clinically used for treating lung cancer.
To examine whether epigenetic modifications are involved in its anticancer activity, we performed a global profiling analysis of H3K4Me3, an epigenomic marker associated with active gene expression, in JFK-treated lung cancer cells.
We identified 11,670 genes with significantly altered status of H3K4Me3 modification following JFK treatment ( P < 0.05 ).
Gene Ontology analysis indicates that these genes are involved in tumor-related pathways, including pathway in cancer, basal cell carcinoma, apoptosis, induction of programmed cell death, regulation of transcription (DNA-templated), intracellular signal transduction, and regulation of peptidase activity.
In particular, we found that the levels of H3K4Me3 at the promoters of SUSD2, CCND2, BCL2A1, and TMEM158 are significantly altered in A549, NCI-H1975, NCI-H1650, and NCI-H2228 cells, when treated with JFK.
Collectively, these findings provide the first evidence that the anticancer activity of JFK involves modulation of histone modification at many cancer-related gene loci.
American Psychological Association (APA)
Lu, Jun& Zhang, Xiaoli& Shen, Tingting& Ma, Chao& Wu, Jun& Kong, Hualei…[et al.]. 2016. Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104335
Modern Language Association (MLA)
Lu, Jun…[et al.]. Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104335
American Medical Association (AMA)
Lu, Jun& Zhang, Xiaoli& Shen, Tingting& Ma, Chao& Wu, Jun& Kong, Hualei…[et al.]. Epigenetic Profiling of H3K4Me3 Reveals Herbal Medicine Jinfukang-Induced Epigenetic Alteration Is Involved in Anti-Lung Cancer Activity. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104335