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Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor
Joint Authors
Xie, Yong-Chao
Ning, Ning
Zhu, Li
Li, Dan-Ning
Feng, Xing
Yang, Xiao-Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Biatractylolide was isolated from ethyl acetate extract of dried Atractylodis Macrocephalae Rhizoma root by multistep chromatographic processing.
Structure of biatractylolide was confirmed by 1H-NMR and 13C-NMR.
The IC50 on acetylcholinesterase (AChE) activity was 6.5458 μg/mL when the control IC50 value of huperzine A was 0.0192 μg/mL.
Molecular Docking Software (MOE) was used to discover molecular sites of action between biatractylolide and AChE protein by regular molecular docking approaches.
Moreover, biatractylolide downregulated the expression of AChE of MEF and 293T cells in a dose-dependent manner.
These results demonstrated that the molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3β.
American Psychological Association (APA)
Xie, Yong-Chao& Ning, Ning& Zhu, Li& Li, Dan-Ning& Feng, Xing& Yang, Xiao-Ping. 2016. Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104354
Modern Language Association (MLA)
Xie, Yong-Chao…[et al.]. Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104354
American Medical Association (AMA)
Xie, Yong-Chao& Ning, Ning& Zhu, Li& Li, Dan-Ning& Feng, Xing& Yang, Xiao-Ping. Primary Investigation for the Mechanism of Biatractylolide from Atractylodis Macrocephalae Rhizoma as an Acetylcholinesterase Inhibitor. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104354