Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice
Joint Authors
Bao, Yanyan
Pan, Xin
Jin, Yahong
Gao, Yingjie
Cui, Xiaolan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Chinese medicines (CMs) have been shown to have some advantages in preventing and controlling tumors.
In this study, we investigated the antitumor effect of ZFSC by establishing a mouse model of HT-1080, A-549, and HCT-8 tumors.
The result showed that tumor volumes of HT-1080 tumor-bearing nude mice in ZFSC low, medium, and high dose groups were lower significantly compared to the model group, and the high dose ZFSC showed the best antitumor effect.
Tumor volumes of A-549 tumor-bearing nude mice in ZFSC low, medium, and high dose groups were lower significantly compared to the model group and showed a good dose-response relationship.
There was no significant effect on human colon cancer, although inhibition trends disappeared in the bar chart.
In order to verify the immunomodulatory effect of ZFSC, ELISA was used to analyze serums IL-2, TNF-α, and IFN in spleens.
The results showed that ZFSC could enhance the immune function of tumor-bearing mice.
ZFSC reduced IFN-γ and TNF-α content in the serum of HT-1080 tumor-bearing mice and inhibit PD1 and PDL1 and suggested that the antitumor mechanism of ZFSC on human fibrosarcoma could be attributed to inhibition of the PDL1/PD1 pathway.
American Psychological Association (APA)
Bao, Yanyan& Pan, Xin& Jin, Yahong& Gao, Yingjie& Cui, Xiaolan. 2016. Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104357
Modern Language Association (MLA)
Bao, Yanyan…[et al.]. Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104357
American Medical Association (AMA)
Bao, Yanyan& Pan, Xin& Jin, Yahong& Gao, Yingjie& Cui, Xiaolan. Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104357