Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice

Joint Authors

Bao, Yanyan
Pan, Xin
Jin, Yahong
Gao, Yingjie
Cui, Xiaolan

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-07-04

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Chinese medicines (CMs) have been shown to have some advantages in preventing and controlling tumors.

In this study, we investigated the antitumor effect of ZFSC by establishing a mouse model of HT-1080, A-549, and HCT-8 tumors.

The result showed that tumor volumes of HT-1080 tumor-bearing nude mice in ZFSC low, medium, and high dose groups were lower significantly compared to the model group, and the high dose ZFSC showed the best antitumor effect.

Tumor volumes of A-549 tumor-bearing nude mice in ZFSC low, medium, and high dose groups were lower significantly compared to the model group and showed a good dose-response relationship.

There was no significant effect on human colon cancer, although inhibition trends disappeared in the bar chart.

In order to verify the immunomodulatory effect of ZFSC, ELISA was used to analyze serums IL-2, TNF-α, and IFN in spleens.

The results showed that ZFSC could enhance the immune function of tumor-bearing mice.

ZFSC reduced IFN-γ and TNF-α content in the serum of HT-1080 tumor-bearing mice and inhibit PD1 and PDL1 and suggested that the antitumor mechanism of ZFSC on human fibrosarcoma could be attributed to inhibition of the PDL1/PD1 pathway.

American Psychological Association (APA)

Bao, Yanyan& Pan, Xin& Jin, Yahong& Gao, Yingjie& Cui, Xiaolan. 2016. Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104357

Modern Language Association (MLA)

Bao, Yanyan…[et al.]. Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104357

American Medical Association (AMA)

Bao, Yanyan& Pan, Xin& Jin, Yahong& Gao, Yingjie& Cui, Xiaolan. Antitumor Effect of Zhihuang Fuzheng Soft Capsules on Tumor-Bearing Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104357

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1104357