Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Metal ions and sulfate are components of atmospheric pollutants that have diverse ways of entering the human body.
We used Drosophila as a model to investigate the effect of Asparagus cochinchinensis (A.
cochinchinensis) extracts on the gut and characterized gut homeostasis following the ingestion of metal ions (copper, zinc, and aluminum).
In this study, we found that the aqueous A.
cochinchinensis extract increased the survival rate, decreased epithelial cell death, and attenuated metal ion-induced gut morphological changes in flies following chronic exposure to metal ions.
In addition, we screened out, by network pharmacology, six natural products (NPs) that could serve as putative active components of A.
cochinchinensis that prevented gut injury.
Altogether, the results of our study provide evidence that A.
cochinchinensis might be an effective phytomedicine for the treatment of metal ion-induced gut injury.
American Psychological Association (APA)
Zhang, Weiyu& Jin, Li Hua. 2016. Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104364
Modern Language Association (MLA)
Zhang, Weiyu& Jin, Li Hua. Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104364
American Medical Association (AMA)
Zhang, Weiyu& Jin, Li Hua. Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104364