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Improvement of Electroacupuncture on APPPS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus
Joint Authors
Miao, Yanhuan
Mo, Yuping
Wang, Xin
Li, Zhigang
Abulizi, Jiawula
Li, Fu
Xue, Weiguo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
To explore the alterations of β-amyloid (Aβ) and low density lipoprotein receptor-related protein-1 (LRP1) in APP/PS1 mice after electroacupuncture (EA) treatment and further to explore the mechanism.
Methods.
Forty 6-month-old APP/PS1 mice were randomly divided into a model group and an EA group, with twenty wild-type mice used as a normal control group.
Mice in the EA group were treated with EA at GV 20 (băi huì) and bilateral KI 1 (yŏng quán) acupoints for 6 weeks.
The Morris water maze was applied to assess the spatial memory in behavior.
Immunohistochemistry (IHC), ELISA, Western blotting, and so forth were used to observe the expression of LRP1 and Aβ.
Results.
The Morris water maze test showed that, compared with the normal control group, the model group’s learning and memory capabilities were significantly decreased (P<0.05; P<0.01).
The EA group was reversed (P<0.05; P<0.01).
The hippocampal expression of Aβ in the EA group was significantly decreased compared to the model group (P<0.01).
The expression of LRP1 in the model group was significantly lower than that in the normal control group (P<0.01); the expression in the EA group was significantly higher than that in the model group (P<0.01).
Conclusions.
EA therapy can improve the learning and memory capabilities of APP/PS1 mice.
The underlying mechanism may lie in the upregulation of an Aβ transport receptor and LRP1.
American Psychological Association (APA)
Wang, Xin& Miao, Yanhuan& Abulizi, Jiawula& Li, Fu& Mo, Yuping& Xue, Weiguo…[et al.]. 2016. Improvement of Electroacupuncture on APPPS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104365
Modern Language Association (MLA)
Wang, Xin…[et al.]. Improvement of Electroacupuncture on APPPS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104365
American Medical Association (AMA)
Wang, Xin& Miao, Yanhuan& Abulizi, Jiawula& Li, Fu& Mo, Yuping& Xue, Weiguo…[et al.]. Improvement of Electroacupuncture on APPPS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aβ and LRP1 in Hippocampus. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104365