Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats
Author
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Postprandial hyperglycemia is a predisposing factor for vascular dysfunction and organ damage.
α-glucosidase is a hydrolytic enzyme that increases the glucose absorption rate and subsequently elevates blood glucose levels.
Garlic (Allium sativum L.) is a rich source of several phytonutrients, including thiosulfinate (THIO).
The aim of this study was to evaluate the ability of THIO, a potent inhibitor of intestinal α-glucosidase, to reduce postprandial blood glucose.
Male albino rats were randomly assigned to five different groups ( n = 10 /group).
Group 1 served as the control group.
Groups 2–5 were injected intraperitoneally with a single dose of streptozotocin (STZ) to induce diabetes.
Group 2 comprised untreated diabetic rats.
Groups 3 and 4 contained diabetic rats that were given THIO orally (20 mg/kg body weight/day and 40 mg/kg body weight/day, resp.).
Group 5 was the positive control having diabetic rats treated orally with acarbose (10 mg/kg body weight/day; positive control).
Diabetic rats treated with THIO displayed a significant blood glucose reduction ( p < 0.001 and < 0.01 by analysis of variance, resp.) and a significant elevation in insulin compared with that of untreated rats.
THIO is an effective noncompetitive intestinal α-glucosidase inhibitor that promotes hypoglycemic action ( p < 0.001 ) in STZ-injected rats.
THIO is a promising agent for the management of postprandial hyperglycemia.
American Psychological Association (APA)
al-Malki, Abdulrahman L.. 2016. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
Modern Language Association (MLA)
al-Malki, Abdulrahman L.. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
American Medical Association (AMA)
al-Malki, Abdulrahman L.. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104371