Ma Huang Tang Suppresses the Production and Expression of Inflammatory Chemokines via Downregulating STAT1 Phosphorylation in HaCaT Keratinocytes
Joint Authors
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Lim, Hye-Sun
Yoo, Sae-Rom
Jin, Seong Eun
Jeong, Soo-Jin
Lee, Mee-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ma huang tang (MHT) is a traditional herbal medicine comprising six medicinal herbs and is used to treat influenza-like illness.
However, the effects of MHT on inflammatory skin diseases have not been verified scientifically.
We investigated determining the inhibitory effects of MHT against inflammation responses in skin using HaCaT human keratinocyte cells.
We found that MHT suppressed production of thymus and activation-regulated chemokine (TARC/CCL17), macrophage-derived chemokine (MDC/CCL22), regulated on activation of normal T-cell expressed and secreted (RANTES/CCL5), and interleukin-8 (IL-8) in tumor necrosis factor-α (TNF-α) and interferon-γ- (IFN-γ-) stimulated HaCaT cells.
Consistently, MHT suppressed the mRNA expression of TARC, MDC, RANTES, and IL-8 in TNF-α and IFN-γ-stimulated cells.
Additionally, MHT inhibited TNF-α and IFN-γ-stimulated signal transducer and activator of transcription 1 (STAT1) phosphorylation in a dose-dependent manner and nuclear translocation in HaCaT cells.
Our finding indicates that MHT inhibits production and expression of inflammatory chemokines in the stimulated keratinocytes by downregulating STAT1 phosphorylation, suggesting that MHT may be a possible therapeutic agent for inflammatory skin diseases.
American Psychological Association (APA)
Lim, Hye-Sun& Seo, Chang-Seob& Jin, Seong Eun& Yoo, Sae-Rom& Lee, Mee-Young& Shin, Hyeun-Kyoo…[et al.]. 2016. Ma Huang Tang Suppresses the Production and Expression of Inflammatory Chemokines via Downregulating STAT1 Phosphorylation in HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104377
Modern Language Association (MLA)
Lim, Hye-Sun…[et al.]. Ma Huang Tang Suppresses the Production and Expression of Inflammatory Chemokines via Downregulating STAT1 Phosphorylation in HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104377
American Medical Association (AMA)
Lim, Hye-Sun& Seo, Chang-Seob& Jin, Seong Eun& Yoo, Sae-Rom& Lee, Mee-Young& Shin, Hyeun-Kyoo…[et al.]. Ma Huang Tang Suppresses the Production and Expression of Inflammatory Chemokines via Downregulating STAT1 Phosphorylation in HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104377