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Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NOcGMP Signaling Pathway in Rats
Joint Authors
Yang, Dan-Li
Li, Li-sheng
Luo, Yun-mei
Liu, Juan
Zhang, Yu
Fu, Xiao-xia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
It has been reported that icariin (ICA) increased contents of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) by improving expression of endothelial nitric oxide synthase (eNOS) and inhibition of phosphodiesterase type 5 (PDE5).
In addition, dysfunction of the NO/cGMP pathway may play a crucial role in the pathogenesis of pulmonary hypertension (PH).
In this study, the potential protective effects of ICA on PH induced by monocrotaline (MCT, 50 mg/kg) singly subcutaneous injection were investigated and the possible mechanisms involved in NO/cGMP pathway were explored in male Sprague Dawley rats.
The results showed that ICA (20, 40, and 80 mg/kg/d) treatment by intragastric administration could significantly ameliorate PH and upregulate the expression of eNOS gene and downregulate the expression of PDE5 gene in MCT-treated rats.
Both ICA (40 mg/kg/d) and L-arginine (200 mg/kg/d), a precursor of NO as positive control, notably increased the contents of NO and cGMP in lung tissue homogenate, which were inversed by treatment with G N -nitro-L-arginine-methyl ester (L-NAME), a NOS inhibitor, and L-NAME-treatment could also inhibit the protective effects of ICA (40 mg/kg/d) on mean pulmonary artery pressure and artery remodeling and tends to inhibit right ventricle hypertrophy index.
In summary, ICA is effective in protecting against MCT-induced PH in rats through enhancement of NO/cGMP signaling pathway in rats.
American Psychological Association (APA)
Li, Li-sheng& Luo, Yun-mei& Liu, Juan& Zhang, Yu& Fu, Xiao-xia& Yang, Dan-Li. 2016. Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NOcGMP Signaling Pathway in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104389
Modern Language Association (MLA)
Li, Li-sheng…[et al.]. Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NOcGMP Signaling Pathway in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104389
American Medical Association (AMA)
Li, Li-sheng& Luo, Yun-mei& Liu, Juan& Zhang, Yu& Fu, Xiao-xia& Yang, Dan-Li. Icariin Inhibits Pulmonary Hypertension Induced by Monocrotaline through Enhancement of NOcGMP Signaling Pathway in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104389