Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats
Joint Authors
Duan, Dongmei
Yang, Xiuyan
Liu, Ping
Tu, Ya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The current study is designed to investigate the antidepressant efficacy of electroacupuncture (EA) treatment by evaluating its effect on the synthesis, metabolism, reuptake, and receptors of 5-hydroxytryptamine (5-HT), so as to clarify the molecular mechanisms of EA for antidepression.
Materials and Methods.
Solitary combined with the chronic unpredictable mild stress (CUMS) was used to establish the rat model with depression.
The depressed rats were supplied with EA treatment for 4 weeks, and the behavior change and the following indices including 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), monoamine oxidase A (MAO-A), tryptophan hydroxylase (TPH), 5-HT transporter (SERT), 5-HT1A, and 5-HT2A in hippocampus and prefrontal cortex were examined.
Results.
EA treatment significantly improved the behavior of rats and increased 5-HT level in hippocampus of depressed rats.
Similarly, EA treatment could significantly increase protein and mRNA expression of TPH and 5-HT1A during 5-HT synthesis process in hippocampus of depressed rats.
However, EA treatment had no effect on the activity of MAO-A and the expression of SERT protein and mRNA.
Conclusion.
Antidepressant efficacy of EA treatment can be accomplished through enhancing 5-HT synthesis, upregulating 5-HT1A level, and improving 5-HT content in brain and synaptic gaps.
American Psychological Association (APA)
Duan, Dongmei& Tu, Ya& Yang, Xiuyan& Liu, Ping. 2016. Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104394
Modern Language Association (MLA)
Duan, Dongmei…[et al.]. Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104394
American Medical Association (AMA)
Duan, Dongmei& Tu, Ya& Yang, Xiuyan& Liu, Ping. Electroacupuncture Restores 5-HT System Deficit in Chronic Mild Stress-Induced Depressed Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104394