Effects of Electroacupuncture Treatment on Bone Cancer Pain Model with Morphine Tolerance
Joint Authors
Sima, Lei
Fan, Bifa
Yan, Longtao
Shui, Yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To explore the efficacy of electroacupuncture treatment in cancer induced bone pain (CIBP) rat model with morphine tolerance and explore changes of calcitonin-gene related peptide (CGRP) expression in dorsal root ganglion (DRG).
Methods.
Forty SD rats were divided into five groups: sham, CIBP (B), CIBP + morphine (BM), CIBP + electroacupuncture (BE), and CIBP + morphine + electroacupuncture (BME).
B, BM, BE, and BME groups were prepared CIBP model.
The latter three groups then accepted morphine, electroacupuncture, and morphine combined electroacupuncture, separately, nine days consecutively (M1 to M9).
Mechanical withdraw threshold (MWT) was evaluated.
Results.
BE group only had differences in M1, M2, and M3 compared to B group ( P < 0.01 ).
From M5, BM group showed significantly decreased MWT.
Electroacupuncture could obtain analgesic effects only at early stage (M1 to M5).
From M5 to M9, BME had the differences with BM group ( P < 0.01 ).
IOD value of CGRP in BM and BME was substantially less than in B group.
CGRP in BME was significantly lower than that in BM group ( P < 0.01 ).
Conclusion.
When used in combination with electroacupuncture, morphine could result in improving analgesic effects and reducing tolerance.
CGRP may be associated with pain behaviors.
American Psychological Association (APA)
Sima, Lei& Fan, Bifa& Yan, Longtao& Shui, Yuan. 2016. Effects of Electroacupuncture Treatment on Bone Cancer Pain Model with Morphine Tolerance. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104398
Modern Language Association (MLA)
Sima, Lei…[et al.]. Effects of Electroacupuncture Treatment on Bone Cancer Pain Model with Morphine Tolerance. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1104398
American Medical Association (AMA)
Sima, Lei& Fan, Bifa& Yan, Longtao& Shui, Yuan. Effects of Electroacupuncture Treatment on Bone Cancer Pain Model with Morphine Tolerance. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104398
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104398