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Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia
Joint Authors
Li, Shao-Dan
Li, Fagen
Liu, Yi
Cao, Ke
Yang, Minghui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
To study the effect of Heweianshen decoction (HAD) on orexin-A and cholecystokinin-8 (CCK-8) expression in rat models of insomnia caused by injecting parachlorophenylalanine (PCPA) intraperitoneally.
Methods.
Fifty male Wistar rats were randomly divided into five groups (10 rats in each group): blank group, model group, and low-, medium-, and high-dose HAD-treated groups.
A rat model of insomnia was established by injecting intraperitoneally with PCPA (300 mg/kg body weight).
Rats were given normal saline (10 mL/kg) or 5.25, 10.5, and 21 g/kg HAD by intragastric administration once a day for 6 days.
After that, the rats were sacrificed to collect the hypothalamus for tests, using radioimmunoassay to detect the expression of orexin-A and CCK-8.
Results.
Heweianshen decoction reduced the expression of orexin-A and increased the expression of CCK-8 in the hypothalamus of rat model of insomnia.
Conclusion.
The therapeutic effect of HAD on insomnia is partially attributed to the decreased expression of orexin-A and increased expression of CCK-8.
American Psychological Association (APA)
Li, Fagen& Li, Shao-Dan& Liu, Yi& Cao, Ke& Yang, Minghui. 2016. Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1104399
Modern Language Association (MLA)
Li, Fagen…[et al.]. Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1104399
American Medical Association (AMA)
Li, Fagen& Li, Shao-Dan& Liu, Yi& Cao, Ke& Yang, Minghui. Effect of Heweianshen Decoction on Orexin-A and Cholecystokinin-8 Expression in Rat Models of Insomnia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1104399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104399