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Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia
Joint Authors
Shukor, Mohd Yunus
Sabullah, Mohd Khalizan
Ahmad, Siti Aqlima
Gunasekaran, Baskaran
Salvamani, Shamala
Shaharuddin, Noor Azmi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inflammation and oxidative stress are believed to contribute to the pathology of several chronic diseases including hypercholesterolemia (elevated levels of cholesterol in blood) and atherosclerosis.
HMG-CoA reductase inhibitors of plant origin are needed as synthetic drugs, such as statins, which are known to cause adverse effects on the liver and muscles.
Amaranthus viridis (A.
viridis) has been used from ancient times for its supposedly medically beneficial properties.
In the current study, different parts of A.
viridis (leaf, stem, and seed) were evaluated for potential anti-HMG-CoA reductase, antioxidant, and anti-inflammatory activities.
The putative HMG-CoA reductase inhibitory activity of A.
viridis extracts at different concentrations was determined spectrophotometrically by NADPH oxidation, using HMG-CoA as substrate.
A.
viridis leaf extract revealed the highest HMG-CoA reductase inhibitory effect at about 71%, with noncompetitive inhibition in Lineweaver-Burk plot analysis.
The leaf extract showed good inhibition of hydroperoxides, 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide (NO), and ferric ion radicals in various concentrations.
A.
viridis leaf extract was proven to be an effective inhibitor of hyaluronidase, lipoxygenase, and xanthine oxidase enzymes.
The experimental data suggest that A.
viridis leaf extract is a source of potent antioxidant and anti-inflammatory agent and may modulate cholesterol metabolism by inhibition of HMG-CoA reductase.
American Psychological Association (APA)
Salvamani, Shamala& Gunasekaran, Baskaran& Shukor, Mohd Yunus& Shaharuddin, Noor Azmi& Sabullah, Mohd Khalizan& Ahmad, Siti Aqlima. 2016. Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104401
Modern Language Association (MLA)
Salvamani, Shamala…[et al.]. Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104401
American Medical Association (AMA)
Salvamani, Shamala& Gunasekaran, Baskaran& Shukor, Mohd Yunus& Shaharuddin, Noor Azmi& Sabullah, Mohd Khalizan& Ahmad, Siti Aqlima. Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104401