Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway
Joint Authors
Zhao, Hongyu
Wang, Yu
Li, Fengchun
Zhang, Zhigang
Zhao, Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Glycyrrhizic acid (GA) is a major active ingredient in licorice.
In our study, the effects of GA on acute kidney injury (AKI) in rats and its underlying molecular mechanisms were investigated.
The sepsis model was produced by caecal ligation and puncture (CLP) in rats.
The molecular and histological experiments were performed in the kidney tissues and serum samples of rats.
According to the results obtained, GA alleviated sepsis-induced AKI by improving the pathological changes, decreasing the levels of blood urea nitrogen (BUN), creatinine (Cre), and increasing the survival rate of rats with AKI significantly.
The production of inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, was markedly inhibited by GA.
Moreover, treatment with GA inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and expression levels of induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in kidney tissues.
Furtherly, the apoptosis in kidney tissue induced by AKI was suppressed by GA.
Finally, GA could inhibit the activation of NF-κB signaling pathway.
Our study suggests that GA alleviates sepsis-induced AKI by inhibiting the NF-κB signaling pathway, which provides a strong evidence for a new approach for treating sepsis-induced AKI.
American Psychological Association (APA)
Zhao, Hongyu& Zhao, Min& Wang, Yu& Li, Fengchun& Zhang, Zhigang. 2016. Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104412
Modern Language Association (MLA)
Zhao, Hongyu…[et al.]. Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104412
American Medical Association (AMA)
Zhao, Hongyu& Zhao, Min& Wang, Yu& Li, Fengchun& Zhang, Zhigang. Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104412