The Classification of Sini Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling
Joint Authors
Cheng, Hung-Tsu
Chen, Chaang-Ray
Li, Chia-Yang
Huang, Chao-Ying
Shu, Wun-Yi
Hsu, Ian C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We investigated the syndromes of the Sini decoction pattern (SDP), a common ZHENG in traditional Chinese medicine (TCM).
The syndromes of SDP were correlated with various severe Yang deficiency related symptoms.
To obtain a common profile for SDP, we distributed questionnaires to 300 senior clinical TCM practitioners.
According to the survey, we concluded 2 sets of symptoms for SDP: (1) pulse feels deep or faint and (2) reversal cold of the extremities.
Twenty-four individuals from Taipei City Hospital, Linsen Chinese Medicine Branch, Taiwan, were recruited.
We extracted the total mRNA of peripheral blood mononuclear cells from the 24 individuals for microarray experiments.
Twelve individuals (including 6 SDP patients and 6 non-SDP individuals) were used as the training set to identify biomarkers for distinguishing the SDP and non-SDP groups.
The remaining 12 individuals were used as the test set.
The test results indicated that the gene expression profiles of the identified biomarkers could effectively distinguish the 2 groups by adopting a hierarchical clustering algorithm.
Our results suggest the feasibility of using the identified biomarkers in facilitating the diagnosis of TCM ZHENGs.
Furthermore, the gene expression profiles of biomarker genes could provide a molecular explanation corresponding to the ZHENG of TCM.
American Psychological Association (APA)
Cheng, Hung-Tsu& Chen, Chaang-Ray& Li, Chia-Yang& Huang, Chao-Ying& Shu, Wun-Yi& Hsu, Ian C.. 2016. The Classification of Sini Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104413
Modern Language Association (MLA)
Cheng, Hung-Tsu…[et al.]. The Classification of Sini Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104413
American Medical Association (AMA)
Cheng, Hung-Tsu& Chen, Chaang-Ray& Li, Chia-Yang& Huang, Chao-Ying& Shu, Wun-Yi& Hsu, Ian C.. The Classification of Sini Decoction Pattern in Traditional Chinese Medicine by Gene Expression Profiling. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104413