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Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease
Joint Authors
Jia, Ge-Liuchang
Wang, Ya
Niu, Ming
Li, Rui-sheng
Zhang, Ya-ming
Zhang, Cong-en
Meng, Ya-kun
Cui, He-rong
Ma, Zhi-jie
Li, Dong-hui
Xiao, Xiao-he
Wang, Jia-Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease.
Currently, there are no recognized medical therapies effective for NAFLD.
Previous studies have demonstrated the effects of total turmeric extract on rats with NAFLD induced by high-fat diet.
In this study, serum metabolomics was employed using UHPLC-Q-TOF-MS to elucidate the underlying mechanisms of HFD-induced NAFLD and the therapeutic effects of TE.
Supervised orthogonal partial least-squares-discriminant analysis was used to discover differentiating metabolites, and pathway enrichment analysis suggested that TE had powerful combined effects of regulating lipid metabolism by affecting glycerophospholipid metabolism, glycerolipid metabolism, and steroid hormone biosynthesis signaling pathways.
In addition, the significant changes in glycerophospholipid metabolism proteins also indicated that glycerophospholipid metabolism might be involved in the therapeutic effect of TE on NAFLD.
Our findings not only supply systematic insight into the mechanisms of NAFLD but also provide a theoretical basis for the prevention or treatment of NAFLD.
American Psychological Association (APA)
Wang, Ya& Niu, Ming& Jia, Ge-Liuchang& Li, Rui-sheng& Zhang, Ya-ming& Zhang, Cong-en…[et al.]. 2016. Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104428
Modern Language Association (MLA)
Wang, Ya…[et al.]. Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104428
American Medical Association (AMA)
Wang, Ya& Niu, Ming& Jia, Ge-Liuchang& Li, Rui-sheng& Zhang, Ya-ming& Zhang, Cong-en…[et al.]. Untargeted Metabolomics Reveals Intervention Effects of Total Turmeric Extract in a Rat Model of Nonalcoholic Fatty Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104428