The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRLlpr Mice
Joint Authors
Li, Ruiming
Huang, Kai-Peng
Zhang, Zhi-Hao
Chen, Xiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to severe multiorgan damage.
Lang Chuang Fang (LCF) is a Chinese herbal medicine that is clinically prescribed for treating SLE.
In this study, we examined the therapeutic effects of LCF granule on lupus-prone MRL/lpr mice.
Female mice were randomly separated into six groups, and LCF treatment groups received LCF granule at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, respectively.
Here, we found that, compared to the MRL/lpr mice, both the spleen coefficient and thymus coefficient were reduced in the LCF granule-treated mice.
There was a marked downregulation in CRP and anti-dsDNA autoantibody and an evident upregulation of CH50 in LCF granule-treated mice.
LCF granule treatment also obviously reduced the proteinuria, BUN, and SCr levels in MRL/lpr mice at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, indicating that LCF granule alleviated the renal injury of MRL/lpr mice.
Furthermore, LCF granule decreased p65 NF-κB levels and increased Sirt1 and Nrf2 levels in the kidney tissues of MRL/lpr mice, which might elucidate the beneficial effects of LCF on lupus nephritis.
In conclusion, this study demonstrates that LCF granule has therapeutic effects on lupus-prone MRL/lpr mice.
American Psychological Association (APA)
Huang, Kai-Peng& Zhang, Zhi-Hao& Li, Ruiming& Chen, Xiao. 2016. The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRLlpr Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104432
Modern Language Association (MLA)
Huang, Kai-Peng…[et al.]. The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRLlpr Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104432
American Medical Association (AMA)
Huang, Kai-Peng& Zhang, Zhi-Hao& Li, Ruiming& Chen, Xiao. The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRLlpr Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104432