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Yi-Zhi-Fang-Dai Formula Protects against A β 1–42 Oligomer Induced Cell Damage via Increasing Hsp70 and Grp78 Expression in SH-SY5Y Cells
Joint Authors
Liu, Lumei
Wan, Wenbin
Chen, Wenjing
Chan, Yuanjin
Shen, Qi
Li, Yaming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Yi-Zhi-Fang-Dai formula (YZFDF) is an experiential prescription used to cure dementia cases like Alzheimer’s disease (AD).
In this study, the main effective compounds of YZFDF have been identified from this formula, and the neuroprotective effect against A β 1–42 oligomer of YZFDF has been tested in SH-SY5Y cells.
Our results showed that YZFDF could increase cell viability and could attenuate endothelial reticula- (ER-) mediated apoptosis.
Evidence indicated that protein folding and endothelial reticula stress (ERS) played an important role in the AD pathological mechanism.
We further explored the expression of Hsp70, an important molecular chaperon facilitating the folding of other proteins, and Grp78, the marker protein of ERS in SH-SY5Y cells.
Data told us that YZFDF pretreatment could influence the mRNA and protein expression of these two proteins.
At last, we also found that YZFDF pretreatment could activate Akt in SH-SY5Y cells.
All these above indicate that YZFDF could be a potent therapeutic candidate for AD treatment.
American Psychological Association (APA)
Liu, Lumei& Wan, Wenbin& Chen, Wenjing& Chan, Yuanjin& Shen, Qi& Li, Yaming. 2016. Yi-Zhi-Fang-Dai Formula Protects against A β 1–42 Oligomer Induced Cell Damage via Increasing Hsp70 and Grp78 Expression in SH-SY5Y Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104434
Modern Language Association (MLA)
Liu, Lumei…[et al.]. Yi-Zhi-Fang-Dai Formula Protects against A β 1–42 Oligomer Induced Cell Damage via Increasing Hsp70 and Grp78 Expression in SH-SY5Y Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104434
American Medical Association (AMA)
Liu, Lumei& Wan, Wenbin& Chen, Wenjing& Chan, Yuanjin& Shen, Qi& Li, Yaming. Yi-Zhi-Fang-Dai Formula Protects against A β 1–42 Oligomer Induced Cell Damage via Increasing Hsp70 and Grp78 Expression in SH-SY5Y Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104434