Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled Trials
Joint Authors
Bu, Huaien
Yu, Chunquan
Zhao, Ye
Cao, Suman
Zhao, Wenli
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ligustrazine is a principal ingredient of chuanxiong.
Concerns regarding the evaluation of the effectiveness of ligustrazine in the treatment of UA have resulted in a meta-analysis combined with recent clinical evidence.
Seven computer databases that included the China hospital knowledge database (CHKD), Wanfang Med Online, the Chinese medical journal database (CMJD), PubMed, Cochrane, Embase (Ovid), and Medline (Ovid) were systematically searched.
We included randomized controlled trials and quasi-randomized controlled trials.
Our systematic review identified 16 RCTs that met our eligibility criteria.
Ligustrazine combined with conventional medicine was associated with an increased rate of marked improvement in symptoms and an increased rate of marked improvement of ECG compared with conventional Western medicine alone.
Additionally, the use of ligustrazine was associated with significant trends in the reduction of the consumption of nitroglycerin and the level of fibrinogen when compared with conventional Western medicine alone.
No firm results were found between the intervention and the control method groups in the reduction of the time of onset or the frequency of acute attack angina due to the high level of heterogeneity.
In conclusion, our meta-analysis found that ligustrazine was associated with some benefits for people with unstable angina.
American Psychological Association (APA)
Cao, Suman& Zhao, Wenli& Bu, Huaien& Zhao, Ye& Yu, Chunquan. 2016. Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104437
Modern Language Association (MLA)
Cao, Suman…[et al.]. Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104437
American Medical Association (AMA)
Cao, Suman& Zhao, Wenli& Bu, Huaien& Zhao, Ye& Yu, Chunquan. Ligustrazine for the Treatment of Unstable Angina: A Meta-Analysis of 16 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104437