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Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation
Joint Authors
Tzeng, Yew-Min
Hsieh, Ya-Ju
Tseng, Sung-Pin
Kuo, Yu-Hsuan
Cheng, Tain-Lu
Chiang, Chiao-Yu
Tsai, Wan-Chi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pancreatic cancer is the eighth leading cause of cancer death worldwide.
Patients with pancreatic cancer are normally diagnosed at an advanced stage and present poor survival rate.
Ovatodiolide (OV), a bioactive macrocyclic diterpenoid isolated from Anisomeles indica, showed cytotoxicity effects in pancreatic cancer cells by inhibiting cell proliferation and inducing apoptosis.
Moreover, not only were cell adhesion and invasion markedly suppressed in a dose-dependent manner, but the mRNA expression of matrix metalloproteinase-9 (MMP-9) and focal adhesion kinase (FAK) was also significantly decreased.
Western blot analysis indicated that OV potently suppressed the phosphorylation of STAT-3 and its upstream kinase including ERK1/2, P38, and AKT Ser473.
Meanwhile, OV inactivated the nuclear factor kappa B (NF-κB) by inhibiting IκB kinase (IKK α/β) activation and the subsequent suppression of inhibitor of kappa B (IκB) phosphorylation.
These results demonstrated that OV could potentially inhibit Mia-PaCa2 cancer cells proliferation and induce apoptosis through modulation of NF-κB and STAT3 pathway.
Moreover, OV suppressed cell invasiveness and interfered with cell-matrix adhesion in Mia-PaCa2 cancer cells by reducing MMP-9 and FAK transcription through suppressing NF-κB and STAT3 pathway.
Taken together, our findings reveal a new therapeutic and antimetastatic potential of ovatodiolide for pancreatic cancer remedy.
American Psychological Association (APA)
Hsieh, Ya-Ju& Tseng, Sung-Pin& Kuo, Yu-Hsuan& Cheng, Tain-Lu& Chiang, Chiao-Yu& Tzeng, Yew-Min…[et al.]. 2016. Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104443
Modern Language Association (MLA)
Hsieh, Ya-Ju…[et al.]. Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104443
American Medical Association (AMA)
Hsieh, Ya-Ju& Tseng, Sung-Pin& Kuo, Yu-Hsuan& Cheng, Tain-Lu& Chiang, Chiao-Yu& Tzeng, Yew-Min…[et al.]. Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104443