Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial
Joint Authors
Lim, Soon Sung
Li, Hong Mei
Hwang, Seung Hwan
Wang, Zhiqiang
Hong, Jae-Seung
Huang, Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To evaluate the antihyperglycemic effect of a standardized extract of the leaves of Morus alba (SEMA), the present study was designed to investigate the α-glucosidase inhibitory effect and acute single oral toxicity as well as evaluate blood glucose reduction in animals and in patients with impaired glucose tolerance in a randomized double-blind clinical trial.
SEMA was found to inhibit α-glucosidase at a fourfold higher level than the positive control (acarbose), in a concentration-dependent manner.
Moreover, blood glucose concentration was suppressed by SEMA in vivo.
Clinical signs and weight changes were observed when conducting an evaluation of the acute toxicity of SEMA through a single-time administration, with clinical observation conducted more than once each day.
After administration of the SEMA, observation was for 14 days; all of the animals did not die and did not show any abnormal symptoms.
In addition, the inhibitory effects of rice coated with SEMA were evaluated in a group of impaired glucose tolerance patients on postprandial glucose and a group of normal persons, and results showed that SEMA had a clear inhibitory effect on postprandial hyperglycemia in both groups.
Overall, SEMA showed excellent potential in the present study as a material for improving postprandial hyperglycemia.
American Psychological Association (APA)
Hwang, Seung Hwan& Li, Hong Mei& Lim, Soon Sung& Wang, Zhiqiang& Hong, Jae-Seung& Huang, Bo. 2016. Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104462
Modern Language Association (MLA)
Hwang, Seung Hwan…[et al.]. Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104462
American Medical Association (AMA)
Hwang, Seung Hwan& Li, Hong Mei& Lim, Soon Sung& Wang, Zhiqiang& Hong, Jae-Seung& Huang, Bo. Evaluation of a Standardized Extract from Morus alba against α-Glucosidase Inhibitory Effect and Postprandial Antihyperglycemic in Patients with Impaired Glucose Tolerance: A Randomized Double-Blind Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104462