Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve
Joint Authors
Alves, Péricles Barreto
Marchioro, M.
Medeiros Venancio, Antonio
Ferreira-da-Silva, Francisco Walber
da Silva-Alves, Kerly Shamyra
de Carvalho Pimentel, Hugo
Macêdo Lima, Matheus
Fraga de Santana, Michele
Batista da Silva, Givanildo
Leal-Cardoso, José Henrique
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The racemate linalool and its levogyrus enantiomer [(−)-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory.
In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L.
(EOOb) derived from Germplasm Bank rich in (−)-LIN content in the excitability of peripheral nervous system were studied.
We used rat sciatic nerve to investigate the EOOb and (−)-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP).
EOOb and (−)-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout.
EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38±0.2 and 0.17±0.0 mg/mL, respectively.
For (−)-LIN, these values were 0.23±0.0 and 0.13±0.0 mg/mL.
Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component.
In conclusion EOOb and (−)-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (−)-LIN in the essential oil.
American Psychological Association (APA)
Medeiros Venancio, Antonio& Ferreira-da-Silva, Francisco Walber& da Silva-Alves, Kerly Shamyra& de Carvalho Pimentel, Hugo& Macêdo Lima, Matheus& Fraga de Santana, Michele…[et al.]. 2016. Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104463
Modern Language Association (MLA)
Medeiros Venancio, Antonio…[et al.]. Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104463
American Medical Association (AMA)
Medeiros Venancio, Antonio& Ferreira-da-Silva, Francisco Walber& da Silva-Alves, Kerly Shamyra& de Carvalho Pimentel, Hugo& Macêdo Lima, Matheus& Fraga de Santana, Michele…[et al.]. Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104463