Systems Pharmacology Uncovers the Multiple Mechanisms of Xijiao Dihuang Decoction for the Treatment of Viral Hemorrhagic Fever
Joint Authors
Zheng, Chunli
Liang, Zongsuo
Liu, Jianling
Pei, Tianli
Mu, Jiexin
Chen, Xuetong
Huang, Chao
Fu, Yingxue
Wang, Yonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Background.
Viral hemorrhagic fevers (VHF) are a group of systemic diseases characterized by fever and bleeding, which have posed a formidable potential threat to public health with high morbidity and mortality.
Traditional Chinese Medicine (TCM) formulas have been acknowledged with striking effects in treatment of hemorrhagic fever syndromes in China’s history.
Nevertheless, their accurate mechanisms of action are still confusing.
Objective.
To systematically dissect the mechanisms of action of Chinese medicinal formula Xijiao Dihuang (XJDH) decoction as an effective treatment for VHF.
Methods.
In this study, a systems pharmacology method integrating absorption, distribution, metabolism, and excretion (ADME) screening, drug targeting, network, and pathway analysis was developed.
Results.
23 active compounds of XJDH were obtained and 118 VHF-related targets were identified to have interactions with them.
Moreover, systematic analysis of drug-target network and the integrated VHF pathway indicate that XJDH probably acts through multiple mechanisms to benefit VHF patients, which can be classified as boosting immune system, restraining inflammatory responses, repairing the vascular system, and blocking virus spread.
Conclusions.
The integrated systems pharmacology method provides precise probe to illuminate the molecular mechanisms of XJDH for VHF, which will also facilitate the application of traditional medicine in modern medicine.
American Psychological Association (APA)
Liu, Jianling& Pei, Tianli& Mu, Jiexin& Zheng, Chunli& Chen, Xuetong& Huang, Chao…[et al.]. 2016. Systems Pharmacology Uncovers the Multiple Mechanisms of Xijiao Dihuang Decoction for the Treatment of Viral Hemorrhagic Fever. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1104464
Modern Language Association (MLA)
Liu, Jianling…[et al.]. Systems Pharmacology Uncovers the Multiple Mechanisms of Xijiao Dihuang Decoction for the Treatment of Viral Hemorrhagic Fever. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1104464
American Medical Association (AMA)
Liu, Jianling& Pei, Tianli& Mu, Jiexin& Zheng, Chunli& Chen, Xuetong& Huang, Chao…[et al.]. Systems Pharmacology Uncovers the Multiple Mechanisms of Xijiao Dihuang Decoction for the Treatment of Viral Hemorrhagic Fever. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1104464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104464