Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System
Joint Authors
Tang, Qianli
Jiang, Qiuyan
Sooranna, Suren R.
Lin, Shike
Feng, Yuanyuan
Zhang, Qi
Wang, Meili
Wang, Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To observe the effects of electroacupuncture on pain threshold of laboring rats and the expression of norepinephrine transporter and α2 adrenergic receptor in the central nervous system to determine the mechanism of the analgesic effect of labor.
120 pregnant rats were divided into 6 groups: a control group, 4 electroacupuncture groups, and a meperidine group.
After interventions, the warm water tail-flick test was used to observe pain threshold.
NE levels in serum, NET, and α2AR mRNA and protein expression levels in the central nervous system were measured.
No difference in pain threshold was observed between the 6 groups before intervention.
After intervention, increased pain thresholds were observed in all groups except the control group with a higher threshold seen in the electroacupuncture groups.
Serum NE levels decreased in the electroacupuncture and MP groups.
Increases in NET and α2AR expression in the cerebral cortex and decreases in enlarged segments of the spinal cord were seen.
Acupuncture increases uptake of NE via cerebral NET and decreases its uptake by spinal NET.
The levels of α2AR are also increased and decreased, respectively, in both tissues.
This results in a decrease in systemic NE levels and may be the mechanism for its analgesic effects.
American Psychological Association (APA)
Tang, Qianli& Jiang, Qiuyan& Sooranna, Suren R.& Lin, Shike& Feng, Yuanyuan& Zhang, Qi…[et al.]. 2016. Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104467
Modern Language Association (MLA)
Tang, Qianli…[et al.]. Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104467
American Medical Association (AMA)
Tang, Qianli& Jiang, Qiuyan& Sooranna, Suren R.& Lin, Shike& Feng, Yuanyuan& Zhang, Qi…[et al.]. Effects of Electroacupuncture on Pain Threshold of Laboring Rats and the Expression of Norepinephrine Transporter and α2 Adrenergic Receptor in the Central Nervous System. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104467