Systems Pharmacology Based Study of the Molecular Mechanism of SiNiSan Formula for Application in Nervous and Mental Diseases
Joint Authors
Shen, Xia
Zhao, Zhenyu
Luo, Xuan
Wang, Hao
Hu, Benxiang
Guo, Zihu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Mental disorder is a group of systemic diseases characterized by a variety of physical and mental discomfort, which has become the rising threat to human life.
Herbal medicines were used to treat mental disorders for thousand years in China in which the molecular mechanism is not yet clear.
Objective.
To systematically explain the mechanisms of SiNiSan (SNS) formula on the treatment of mental disorders.
Method.
A systems pharmacology method, with ADME screening, targets prediction, and DAVID enrichment analysis, was employed as the principal approach in our study.
Results.
60 active ingredients of SNS formula and 187 mental disorders related targets were discovered to have interactions with them.
Furthermore, the enrichment analysis of drug-target network showed that SNS probably acts through “multi-ingredient, multitarget, and multisystems” holistic coordination in different organs pattern by indirectly regulating the nutritional and metabolic pathway even their serial complications.
Conclusions.
Our research provides a reference for the molecular mechanism of medicinal herbs in the treatment of mental disease on a systematic level.
Hopefully, it will also provide a theoretical basis for the discovery of lead compounds of natural medicines for other diseases based on traditional medicine.
American Psychological Association (APA)
Shen, Xia& Zhao, Zhenyu& Luo, Xuan& Wang, Hao& Hu, Benxiang& Guo, Zihu. 2016. Systems Pharmacology Based Study of the Molecular Mechanism of SiNiSan Formula for Application in Nervous and Mental Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104473
Modern Language Association (MLA)
Shen, Xia…[et al.]. Systems Pharmacology Based Study of the Molecular Mechanism of SiNiSan Formula for Application in Nervous and Mental Diseases. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104473
American Medical Association (AMA)
Shen, Xia& Zhao, Zhenyu& Luo, Xuan& Wang, Hao& Hu, Benxiang& Guo, Zihu. Systems Pharmacology Based Study of the Molecular Mechanism of SiNiSan Formula for Application in Nervous and Mental Diseases. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104473