Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice
Joint Authors
Yang, In Jun
Lee, Dong-Ung
Shin, Heung-Mook
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Valencene (VAL) isolated from Cyperus rotundus possesses various biological effects such as antiallergic and antimelanogenesis activity.
We investigated the effect of VAL on atopic dermatitis (AD) skin lesions and their molecular mechanisms.
We topically applied VAL to 1-chloro-2,4-dinitrobenzene (DNCB) sensitized NC/Nga mice.
Modified scoring atopic dermatitis index, scratching behavior, and histological/immunohistochemical staining were used to monitor disease severity.
RT-PCR, western blotting, and enzyme-linked immunosorbent assay were used to determine the level of IgE, proinflammatory cytokines/chemokines production, and skin barrier proteins expression.
Topical application of VAL significantly reduced AD-like symptoms and recovered decreased expression of filaggrin in DNCB-sensitized NC/Nga mice.
The levels of serum IgE, IL-1β, IL-6, and IL-13 in skin/splenic tissue were reduced.
In vitro studies using TNF-α and IFN-γ treated HaCaT cells revealed that VAL inhibited the exaggerated expression of Th2 chemokines including TARC/CCL17, MDC/CCL22, and proinflammatory chemokines such as CXCL8, GM-CSF, and I-CAM through blockade of the NF-κB pathway.
In addition, expression of the skin barrier protein, involucrin, was also increased by VAL treatment.
VAL inhibited the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells.
These results suggest that VAL may serve as a potential therapeutic option for AD.
American Psychological Association (APA)
Yang, In Jun& Lee, Dong-Ung& Shin, Heung-Mook. 2016. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104493
Modern Language Association (MLA)
Yang, In Jun…[et al.]. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104493
American Medical Association (AMA)
Yang, In Jun& Lee, Dong-Ung& Shin, Heung-Mook. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NCNga Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104493