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Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats
Joint Authors
Tanvir, E. M.
Khalil, Ibrahim
Parvez, Mashud
Ahmed, Romana
Islam, Md. Aminul
Das, Sagarika
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Paul, Sudip
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although Citrus macroptera (Rutaceae), an indigenous fruit in Bangladesh, has long been used in folk medicine, however, there is a lack of information concerning its protective effects against oxidative damage.
The protective effects of an ethanol extract of Citrus macroptera (EECM) against acetaminophen-induced hepatotoxicity and nephrotoxicity were investigated in rats.
Rats (treatment groups) were pretreated with EECM at doses of 250, 500, and 1000 mg/kg, respectively, orally for 30 days followed by acetaminophen administration.
Silymarin (100 mg/kg) was administered as a standard drug over a similar treatment period.
Our findings indicated that oral administration of acetaminophen induced severe hepatic and renal injuries associated with oxidative stress, as observed by 2-fold higher lipid peroxidation (TBARS) compared to control.
Pretreatment with EECM prior to acetaminophen administration significantly improved all investigated biochemical parameters, that is, transaminase activities, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transferase activities and total bilirubin, total cholesterol, triglyceride and creatinine, urea, uric acid, sodium, potassium and chloride ions, and TBARS levels.
These findings were confirmed by histopathological examinations.
The improvement was prominent in the group that received 1000 mg/kg EECM.
These findings suggested that C.
macroptera fruit could protect against acetaminophen-induced hepatonephrotoxicity, which might be via the inhibition of lipid peroxidation.
American Psychological Association (APA)
Paul, Sudip& Islam, Md. Aminul& Tanvir, E. M.& Ahmed, Romana& Das, Sagarika& Rumpa, Nur-E-Noushin…[et al.]. 2016. Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104508
Modern Language Association (MLA)
Paul, Sudip…[et al.]. Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104508
American Medical Association (AMA)
Paul, Sudip& Islam, Md. Aminul& Tanvir, E. M.& Ahmed, Romana& Das, Sagarika& Rumpa, Nur-E-Noushin…[et al.]. Satkara (Citrus macroptera) Fruit Protects against Acetaminophen-Induced Hepatorenal Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104508