Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis
Joint Authors
Li, Fu-Lun
Xu, Rong
Chen, Jie
Xiao, Qing-qing
Li, Bin
Li, Xin
Li, Su
Zhou, Min
Fan, Bin
Wu, Min-feng
Peng, Shi-guang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
To determine whether immunological serum markers IFN-γ, IL-4, IL-17, IL-23, IL-6, TNF-α, and IL-10 are elevated or decreased in patients compared with healthy controls.
Methods.
A complete search of the literature on this topic within the past 30 years was conducted across seven databases.
Seventeen studies including 768 individuals were identified.
Differences in serum marker levels between subjects and controls were pooled as MDs using the random-effects model.
Results.
The pooled MDs were higher in patients than in healthy controls for IFN-γ (MD 24.9, 95% CI 12.36–37.43), IL-17 (MD 28.92, 95% CI 17.44–40.40), IL-23 (MD 310.60, 95% CI 4.96–616.24), and TNF-α (MD 19.84, 95% CI 13.80–25.87).
Pooled IL-4 (MD −13.5, 95% CI −17.74–−9.26) and IL-10 (MD −10.33, 95% CI −12.03–−8.63) levels were lower in patients.
Conclusion.
The pooled analyses suggest that levels of IFN-γ, IL-17, IL-23, and TNF-α are significantly elevated and that levels of IL-4 and IL-10 are significantly decreased in sera of patients with psoriasis vulgaris of blood-heat syndrome.
Measuring progression of blood-heat syndrome of psoriasis vulgaris will require additional high-quality data, with a low risk of bias and adequate sample sizes, before and after antipsoriatic therapy.
American Psychological Association (APA)
Li, Xin& Xiao, Qing-qing& Li, Fu-Lun& Xu, Rong& Fan, Bin& Wu, Min-feng…[et al.]. 2016. Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104510
Modern Language Association (MLA)
Li, Xin…[et al.]. Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104510
American Medical Association (AMA)
Li, Xin& Xiao, Qing-qing& Li, Fu-Lun& Xu, Rong& Fan, Bin& Wu, Min-feng…[et al.]. Immune Signatures in Patients with Psoriasis Vulgaris of Blood-Heat Syndrome: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104510