Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
Joint Authors
Choue, Ryowon
Lee, Hansongyi
Kim, Hyerang
Lim, Hyunjung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Dyslipidemia has been well-known as a common metabolic disorder contributing to cardiovascular disease.
The aim of this study was to evaluate the effect of the Pinus koraiensis needle extracts (PKE) on the blood cholesterol and oxidative stress.
Method.
We conducted a 12-week randomized, double-blinded controlled trial to examine the effect of PKE on blood lipid profiles in adults with borderline dyslipidemia.
Thirty-three eligible persons were recruited and randomly assigned into PKE ( n = 20 ) and placebo groups ( n = 13 ).
Serum lipids including total cholesterol, low-density lipoprotein- (LDL-) cholesterol, high-density lipoprotein- (HDL-) cholesterol, very low-density lipoprotein- (VLDL-) cholesterol, and triglyceride were measured before and after trial.
Serum insulin, glucose, and antioxidant indicators were also analyzed before and after trial and anthropometry and blood pressure were measured every 4 weeks.
Results.
After 12 weeks, PKE statically significant decreases in systolic blood pressure ( p < 0.05 ) and waist circumference ( p < 0.05 ) were observed.
Also, VLDL-cholesterol significantly decreased (from 24.4 ± 10.0 mg/dL at baseline to 18.4 ± 4.1 mg/dL after 12 weeks) ( p < 0.05 ) and superoxide dismutase (SOD) increased ( 6.12 ± 0.41 U/mL to 9.06 ± 0.62 U/mL) ( p < 0.01 ) in PKE group.
However, after adjustment with WC, VLDL-cholesterol was not significant between groups ( p = 0.095 ) and while SOD remained significant between groups ( p = 0.013 ).
Conclusion.
The results show that PKE was effective in improving the superoxide dismutase in the individuals with borderline dyslipidemia.
American Psychological Association (APA)
Lee, Hansongyi& Kim, Hyerang& Choue, Ryowon& Lim, Hyunjung. 2016. Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104518
Modern Language Association (MLA)
Lee, Hansongyi…[et al.]. Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104518
American Medical Association (AMA)
Lee, Hansongyi& Kim, Hyerang& Choue, Ryowon& Lim, Hyunjung. Evaluation of the Effects of Pinus koraiensis Needle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104518