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Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control
Joint Authors
Wang, Yuanjun
Fu, Chongluo
Xuan, Hongzhuan
Wang, Yuehua
Li, Aifeng
Peng, Wenjun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To understand the material basis of antitumor activity of Chinese propolis water extract (CPWE), we developed a simple and efficient method using macroporous absorptive resin coupled with preparative high performance liquid chromatography and separated and purified eleven chemical components (caffeic acid, ferulic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, pinobanksin, caffeic acid benzyl ester, caffeic acid phenethyl ester, apigenin, pinocembrin, chrysin, and galangin) from CPWE; then we tested the antitumor activities of these eleven components using different human tumor cell lines (MCF-7, MDA-MB-231, HeLa, and A549).
Furthermore, cell migration, procaspase 3 level, and reactive oxygen species (ROS) of effective components from CPWE were investigated.
Our data showed that antitumor activities of the eleven components from CPWE were different from each other.
CPWE and its effective components induced apoptosis by inhibiting tumor cell migration, activating caspase 3, and promoting ROS production.
It can be deduced that the antitumor effects of propolis did not depend on a single component, and there must exist “bioactive components,” which also provides a new idea for Chinese propolis quality control.
American Psychological Association (APA)
Xuan, Hongzhuan& Wang, Yuehua& Li, Aifeng& Fu, Chongluo& Wang, Yuanjun& Peng, Wenjun. 2016. Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104524
Modern Language Association (MLA)
Xuan, Hongzhuan…[et al.]. Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104524
American Medical Association (AMA)
Xuan, Hongzhuan& Wang, Yuehua& Li, Aifeng& Fu, Chongluo& Wang, Yuanjun& Peng, Wenjun. Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104524