An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
Joint Authors
Somasekharan, Syam Prakash
El-Naggar, Amal
Sorensen, Poul H.
Cheng, Hongwei
Wang, Yuzhuo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Research on marine natural products as potential anticancer agents is still limited.
In the present study, an aqueous extract of a Canadian marine microalgal preparation was assessed for anticancer activities using various assays and cell lines of human cancers, including lung, prostate, stomach, breast, and pancreatic cancers, as well as an osteosarcoma.
In vitro, the microalgal extract exhibited marked anticolony forming activity.
In addition, it was more toxic, as indicated by increased apoptosis, to nonadherent cells (grown in suspension) than to adherent cells.
In vivo, an antimetastatic effect of the extract was observed in NOD-SCID mice carrying subrenal capsule xenografts of PC3 prostate cancer cells.
The results of the present study suggest that the antimetastatic effect of the aqueous microalgal extract is based on inhibition of colony forming ability of cancer cells and the preferential killing of suspended cancer cells.
Further research aimed at identification of the molecular basis of the anticancer activities of the microalgal extract appears to be warranted.
American Psychological Association (APA)
Somasekharan, Syam Prakash& El-Naggar, Amal& Sorensen, Poul H.& Wang, Yuzhuo& Cheng, Hongwei. 2016. An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104530
Modern Language Association (MLA)
Somasekharan, Syam Prakash…[et al.]. An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104530
American Medical Association (AMA)
Somasekharan, Syam Prakash& El-Naggar, Amal& Sorensen, Poul H.& Wang, Yuzhuo& Cheng, Hongwei. An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104530