Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis
Joint Authors
Hwang, Guang-Yuh
Wang, Shun-Ping
Lin, Shih-Chao
Li, Shiming
Chao, Ya-Hsuan
Lin, Chi-Chen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the exploration of potential therapeutic agents for rheumatoid arthritis (RA), DBA/1J mice are used as the RA model of collagen-induced arthritis (CIA).
Phloretin, a flavonoid compound extracted from Prunus mandshurica, has been found to exhibit anti-inflammatory activity, making it a potential candidate for treatment of RA.
The objective of this study was to evaluate the therapeutic effects of phloretin on CIA mice.
CIA mice were dosed daily with phloretin at either 50 or 100 mg/kg among two treatment groups.
CIA treated mice showed mitigation of clinical symptoms of RA in addition to reduced inflammation of hind-limbs compared to mice who did not receive phloretin.
Histological analysis showed that phloretin suppressed the severity of RA and effectively mitigated joint inflammation and cartilage- and bone-destruction via reducing proinflammatory cytokine productions (TNF-α, IL-6, IL-1β, and IL-17).
This was at least partially mediated by causing inadequate splenocyte activation and proliferation.
Moreover, phloretin-treated CIA mice showed decreased oxidative stress and diminished levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) in paw tissues as well as reduced productivity of anti-collagen antibodies in serum.
We have concluded that phloretin could be a potent and effective antiarthritis agent, demonstrating anti-inflammatory, antioxidative, and immunomodulatory effects in CIA mice.
American Psychological Association (APA)
Wang, Shun-Ping& Lin, Shih-Chao& Li, Shiming& Chao, Ya-Hsuan& Hwang, Guang-Yuh& Lin, Chi-Chen. 2016. Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104536
Modern Language Association (MLA)
Wang, Shun-Ping…[et al.]. Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104536
American Medical Association (AMA)
Wang, Shun-Ping& Lin, Shih-Chao& Li, Shiming& Chao, Ya-Hsuan& Hwang, Guang-Yuh& Lin, Chi-Chen. Potent Antiarthritic Properties of Phloretin in Murine Collagen-Induced Arthritis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104536