Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum
Joint Authors
Viau, Cassiana Macagnan
Moura, Dinara Jaqueline
Pflüger, Pricila
Facundo, Valdir Alves
Saffi, Jenifer
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Combretum leprosum Mart., a member of the Combretaceae family, is a traditionally used Brazilian medicinal plant, although no evidence in the literature substantiates its antioxidant action and the safety of its use.
We evaluated the antioxidant properties of the ethanolic extract (EE) from flowers of C.
leprosum and its isolated products 5,3′-dihydroxy-3,7,4′-trimethoxyflavone (FCL2) and 5,3′,4′-trihydroxy-3,7-dimethoxyflavone (FCL5) in Saccharomyces cerevisiae strains proficient and deficient in antioxidant defenses.
Their mutagenic activity was also assayed in S.
cerevisiae, whereas cytotoxic and genotoxic properties were evaluated by MTT and Comet Assays, respectively, in V79 cells.
We show that the EE, FCL2, and FCL5 have a significant protective effect against H2O2.
FCL2 showed a better antioxidant action, which can be related to the activation of the 3′-OH in the presence of a methoxyl group at 4′ position in the B-ring of the molecule, while flavonoids did not induce mutagenesis in yeast, and the EE was mutagenic at high concentrations.
The toxicity of these compounds in V79 cells increases from FCL2 = FCL5 < EE; although not cytotoxic, FCL5 induced an increase in DNA damage.
The antioxidant effect, along with the lower toxicity and the absence of genotoxicity, suggests that FCL2 could be suitable for pharmacological use.
American Psychological Association (APA)
Viau, Cassiana Macagnan& Moura, Dinara Jaqueline& Pflüger, Pricila& Facundo, Valdir Alves& Saffi, Jenifer. 2016. Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104537
Modern Language Association (MLA)
Viau, Cassiana Macagnan…[et al.]. Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104537
American Medical Association (AMA)
Viau, Cassiana Macagnan& Moura, Dinara Jaqueline& Pflüger, Pricila& Facundo, Valdir Alves& Saffi, Jenifer. Structural Aspects of Antioxidant and Genotoxic Activities of Two Flavonoids Obtained from Ethanolic Extract of Combretum leprosum. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104537