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The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis
Joint Authors
Chen, Liguo
Feng, Zhitao
Xu, Juan
He, Guochao
Cao, Meiqun
Duan, Lihong
Wu, Zhengzhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the efficacy and safety of the total glucosides of peony (TGP) and leflunomide (LEF) for the treatment of rheumatoid arthritis (RA).
Methods.
Randomized controlled trials (RCTs) on the efficacy and safety of the combination of TGP and LEF versus LEF alone for the treatment of RA were retrieved by searching PubMed, EMBASE, Cochrane Library, the China National Knowledge Infrastructure database, and Wanfang database.
Results.
Eight RCTs including 643 RA patients were included in the present meta-analysis.
The quality of included studies was poor.
The levels of ESR (P<0.0001), CRP (P<0.0001), and RF (P<0.0001) in RA patients who received the combination of TGP and LEF were significantly lower than RA patients who received LEF therapy alone.
The pooled results suggest that the combination of TGP and LEF caused less abnormal liver function than LEF alone (P=0.02).
No significant difference in the gastrointestinal discomfort was identified between the combination of TGP and LEF and LEF alone groups (P=0.18).
Conclusion.
The combination of TGP and LEF in treatment of RA presented the characteristics of notably decreasing the levels of laboratory indexes and higher safety in terms of liver function.
However, this conclusion should be further investigated based on a larger sample size.
American Psychological Association (APA)
Feng, Zhitao& Xu, Juan& He, Guochao& Cao, Meiqun& Duan, Lihong& Chen, Liguo…[et al.]. 2016. The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104538
Modern Language Association (MLA)
Feng, Zhitao…[et al.]. The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104538
American Medical Association (AMA)
Feng, Zhitao& Xu, Juan& He, Guochao& Cao, Meiqun& Duan, Lihong& Chen, Liguo…[et al.]. The Efficacy and Safety of the Combination of Total Glucosides of Peony and Leflunomide for the Treatment of Rheumatoid Arthritis: A Systemic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104538