Comparing the Efficacy of Concomitant Therapy with Sequential Therapy as the First-Line Therapy of Helicobacter pylori Eradication
Joint Authors
Cheung, Dae Young
Jung, Sung Min
Kim, Il
Seong, Hyeonjin
Kim, Jin Il
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The decline of Helicobacter pylori (H.
pylori) eradication rates with standard triple therapy resulted in a search for novel therapies for first-line therapy of H.
pylori infection.
Aim.
The aim of the study is to compare the efficacy of concomitant therapy with sequential therapy as the first-line therapy of H.
pylori eradication.
Methods.
We reviewed medical records of patients who were confirmed to have H.
pylori infection and received eradication treatment from September 2012 to March 2015.
The concomitant group was treated with rabeprazole, amoxicillin, clarithromycin, and metronidazole for 7 days.
The sequential group was treated with rabeprazole and amoxicillin for 5 days and then rabeprazole, clarithromycin, and metronidazole for an additional 5 days.
Six weeks after the treatment period, patients in both groups underwent 13C-Urea breath test (UBT) to confirm H.
pylori eradication.
Results.
The eradication rate was 90.3% in the concomitant group and 85.5% in the sequential group.
However, the eradication rates between the two groups showed no statistical difference ( P = 0.343 ).
Conclusion.
No statistical difference was found in eradication rates between the two groups.
However, in areas where antibiotic resistance is high, concomitant therapy may be more effective than sequential therapy for H.
pylori eradication.
American Psychological Association (APA)
Jung, Sung Min& Cheung, Dae Young& Kim, Jin Il& Kim, Il& Seong, Hyeonjin. 2015. Comparing the Efficacy of Concomitant Therapy with Sequential Therapy as the First-Line Therapy of Helicobacter pylori Eradication. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104584
Modern Language Association (MLA)
Jung, Sung Min…[et al.]. Comparing the Efficacy of Concomitant Therapy with Sequential Therapy as the First-Line Therapy of Helicobacter pylori Eradication. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1104584
American Medical Association (AMA)
Jung, Sung Min& Cheung, Dae Young& Kim, Jin Il& Kim, Il& Seong, Hyeonjin. Comparing the Efficacy of Concomitant Therapy with Sequential Therapy as the First-Line Therapy of Helicobacter pylori Eradication. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104584