Worldwide Incidence of Colorectal Cancer, Leukemia, and Lymphoma in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis

Abstract EN

Background/Aims.

Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC).

In addition, there may be an association between leukemia and lymphoma and IBD.

We conducted a systematic review and meta-analysis of the IBD literature to estimate the incidence of CRC, leukemia, and lymphoma in adult IBD patients.

Methods.

Studies were identified by a literature search of PubMed, Cochrane Library, Medline, Web of Science, Scopus, EMBASE, and ProQuest Dissertations and Theses.

Pooled incidence rates (per 100,000 person-years [py]) were calculated through use of a random effects model, unless substantial heterogeneity prevented pooling of estimates.

Several stratified analyses and metaregression were performed to explore potential study heterogeneity and bias.

Results.

Thirty-six articles fulfilled the inclusion criteria.

For CRC, the pooled incidence rate in CD was 53.3/100,000 py (95% CI 46.3–60.3/100,000).

The incidence of leukemia was 1.5/100,000 py (95% CI −0.06–3.0/100,000) in IBD, 0.3/100,000 py (95% CI −1.0–1.6/100,000) in CD, and 13.0/100,000 py (95% CI 5.8–20.3/100,000) in UC.

For lymphoma, the pooled incidence rate in CD was 0.8/100,000 py (95% CI −0.4–2.1/100,000).

Substantial heterogeneity prevented the pooling of other incidence estimates.

Conclusion.

The incidence of CRC, leukemia, and lymphoma in IBD is low.