The Role of Mast Cells in Irritable Bowel Syndrome
Joint Authors
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, but its treatment is unsatisfactory as its pathophysiology is multifactorial.
The putative factors of IBS pathophysiology are visceral hypersensitivity and intestinal dysmotility, also including psychological factors, dysregulated gut-brain axis, intestinal microbiota alterations, impaired intestinal permeability, and mucosal immune alterations.
Recently, mucosal immune alterations have received much attention with the role of mast cells in IBS.
Mast cells are abundant in the intestines and function as intestinal gatekeepers at the interface between the luminal environment in the intestine and the internal milieu under the intestinal epithelium.
As a gatekeeper at the interface, mast cells communicate with the adjacent cells such as epithelial, neuronal, and other immune cells throughout the mediators released when they themselves are activated.
Many studies have suggested that mast cells play a role in the pathophysiology of IBS.
This review will focus on studies of the role of mast cell in IBS and the limitations of studies and will also consider future directions.
American Psychological Association (APA)
Lee, Kang Nyeong& Lee, Oh Young. 2016. The Role of Mast Cells in Irritable Bowel Syndrome. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104606
Modern Language Association (MLA)
Lee, Kang Nyeong& Lee, Oh Young. The Role of Mast Cells in Irritable Bowel Syndrome. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104606
American Medical Association (AMA)
Lee, Kang Nyeong& Lee, Oh Young. The Role of Mast Cells in Irritable Bowel Syndrome. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104606