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Dysfunctions in the Mature Dendritic Cells Are Associated with the Presence of Metastases of Colorectal Cancer in the Surrounding Lymph Nodes
Joint Authors
Zareba, Konrad
Pryczynicz, Anna
Kemona, Andrzej
Cepowicz, Dariusz
Hołody-Zaręba, Joanna
Guzińska-Ustymowicz, Katarzyna
Kedra, Boguslaw
Gryko, Mariusz
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Dendritic cells play a key role in the antigen presentation and T cell activation.
The aim of this study was a detailed analysis of the presence of mature dendritic cells (CD 83 positive) in colorectal cancer in correlation with selected clinicopathological parameters.
The presence of mature dendritic cells (mDCs) was determined immunohistochemically using the anti-CD83 antibody.
The morphometric analysis of the mDCs was performed in the normal colon wall adjacent to the cancerous tumor as well as in the front of the tumor and in the main mass of the cancerous tumor.
Decrease in mDCs in the front and in the main tumor mass was observed.
The increase in the number of mDCs in both of these locations was associated with the presence of metastases in the nearby lymph nodes (p<0.05 and p<0.01).
Furthermore, the increase in the proportion of mDCs in the main tumor mass was associated with the presence of the invasion of tumor cells into the blood and lymph vessels (p<0.01).
The increase in the amount of mDCs in the cancerous tumor is associated with the invasiveness of the tumor and especially with the metastasis to the surrounding lymph nodes.
American Psychological Association (APA)
Pryczynicz, Anna& Cepowicz, Dariusz& Zareba, Konrad& Gryko, Mariusz& Hołody-Zaręba, Joanna& Kedra, Boguslaw…[et al.]. 2015. Dysfunctions in the Mature Dendritic Cells Are Associated with the Presence of Metastases of Colorectal Cancer in the Surrounding Lymph Nodes. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104615
Modern Language Association (MLA)
Pryczynicz, Anna…[et al.]. Dysfunctions in the Mature Dendritic Cells Are Associated with the Presence of Metastases of Colorectal Cancer in the Surrounding Lymph Nodes. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1104615
American Medical Association (AMA)
Pryczynicz, Anna& Cepowicz, Dariusz& Zareba, Konrad& Gryko, Mariusz& Hołody-Zaręba, Joanna& Kedra, Boguslaw…[et al.]. Dysfunctions in the Mature Dendritic Cells Are Associated with the Presence of Metastases of Colorectal Cancer in the Surrounding Lymph Nodes. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104615