Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis
Joint Authors
Huang, Ben
Ni, Mengdong
Chen, Chen
Feng, Yang
Cai, Sanjun
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
In general, younger age is associated with better survival in patients with colon cancer.
In this study, we aim to analyze the impact of age on cancer-specific survival (CSS) in patients with signet-ring cell carcinoma (SRCC) of the colon, a particularly aggressive type of colon cancer.
Methods.
Information on patients with SRCC of the colon with no distant metastasis was extracted from the US Surveillance, Epidemiology, and End Results (SEER) database.
An X-tile plot was used to determine the optimal cutoff age at diagnosis.
Results.
A total of 776 patients were included in data analysis.
The X-tile program revealed an optimal cutoff at 35 years of age.
A higher percentage of stage III disease and a higher percentage of N2 disease were observed in patients ≤ 35 years of age.
The multivariate Cox proportional model demonstrated that patients ≤ 35 years of age were more likely to have a poorer survival outcome compared with patients aged >35 years (HR 1.411, 95% CI 1.032–1.929, and P=0.031).
Conclusion.
In contrast to the association of younger age with better survival in colon cancer patients, younger age (≤35 years) is associated with poorer survival outcome in patients with SRCC of the colon without distant metastasis.
American Psychological Association (APA)
Huang, Ben& Ni, Mengdong& Chen, Chen& Feng, Yang& Cai, Sanjun. 2016. Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104638
Modern Language Association (MLA)
Huang, Ben…[et al.]. Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104638
American Medical Association (AMA)
Huang, Ben& Ni, Mengdong& Chen, Chen& Feng, Yang& Cai, Sanjun. Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104638