The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity
Joint Authors
He, Qitian
He, Quan
Qin, Xue
Li, Shan
Li, Taijie
Xie, Li
Deng, Yan
He, Yu
Chen, Yongbin
Wei, Zhifu
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Red cell distribution width (RDW) and platelet-lymphocyte ratio (PLR) have been studied in a variety of etiological diseases.
We aim to investigate the relationship between RDW and PLR and the severity of hepatitis C virus- (HCV-) related liver disease.
Methods.
We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls.
Hematological and virological parameters and liver function biomarkers of HCV-related patients at admission were recorded.
Results.
RDW, RDW-to-platelet (RPR), and 1/PLR values in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients and healthy controls (all P<0.001).
The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), and fibrosis index based on the four factors (FIB-4) scores in HCV-related cirrhosis patients were significantly higher than in chronic HCV patients (all P<0.001).
The areas under the curve of the RDW, RPR, and 1/PLR for predicting cirrhosis were 0.791, 0.960, and 0.713, respectively.
Bivariate logistic regression analysis showed that RDW could independently predict the presence of cirrhosis in chronic HCV patients.
Conclusions.
RDW, RPR, and PLR may be potential markers for estimating HCV severity.
American Psychological Association (APA)
He, Qitian& He, Quan& Qin, Xue& Li, Shan& Li, Taijie& Xie, Li…[et al.]. 2016. The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104642
Modern Language Association (MLA)
He, Qitian…[et al.]. The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1104642
American Medical Association (AMA)
He, Qitian& He, Quan& Qin, Xue& Li, Shan& Li, Taijie& Xie, Li…[et al.]. The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104642