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Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats
Joint Authors
Ceranowicz, Piotr
Cieszkowski, Jakub
Kuśnierz-Cabala, Beata
Dembiński, Artur
Gałązka, Krystyna
Warzecha, Zygmunt
Dembiński, Marcin
Gosiewski, Tomasz
Bulanda, Małgorzata
Konturek, Peter Christopher
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals.
The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of acetic acid-induced colitis.
Methods.
Colitis was induced in male Wistar rats by rectal enema with 3.5% acetic acid solution.
Rifaximin (50 mg/kg/dose) and/or Mutaflor (109 CFU/dose) were given intragastrically once a day.
The severity of colitis was assessed at the 8th day after induction of inflammation.
Results.
Treatment with rifaximin significantly accelerated the healing of colonic damage.
This effect was associated with significant reversion of the acetic acid-evoked decrease in mucosal blood flow and DNA synthesis.
Moreover, administration of rifaximin significantly reduced concentration of proinflammatory TNF-α and activity of myeloperoxidase in colonic mucosa.
Mutaflor given alone was without significant effect on activity of colitis.
In contrast, Mutaflor given in combination with rifaximin significantly enhanced therapeutic effect of rifaximin.
Moreover, Mutaflor led to settle of the colon by EcN and this effect was augmented by pretreatment with rifaximin.
Conclusion.
Rifaximin and Mutaflor exhibit synergic anti-inflammatory and therapeutic effect in acetic acid-induced colitis in rats.
American Psychological Association (APA)
Dembiński, Artur& Warzecha, Zygmunt& Ceranowicz, Piotr& Dembiński, Marcin& Cieszkowski, Jakub& Gosiewski, Tomasz…[et al.]. 2016. Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104648
Modern Language Association (MLA)
Dembiński, Artur…[et al.]. Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104648
American Medical Association (AMA)
Dembiński, Artur& Warzecha, Zygmunt& Ceranowicz, Piotr& Dembiński, Marcin& Cieszkowski, Jakub& Gosiewski, Tomasz…[et al.]. Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104648