Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines
Joint Authors
Huang, Zhihui
Chu, Hua
Fox, Mark
Zheng, Xia
Deng, Yanyong
Long, Yanqin
Du, Lijun
Xu, Fei
Dai, Ning
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS).
Psychosocial factors and low-grade colonic mucosal immune activation have been suggested to play important roles in the pathophysiology of IBS.
In total, 94 patients with IBS and 13 healthy volunteers underwent a 10 g lactulose hydrogen breath test (HBT) with concurrent T c 99 m scintigraphy.
All participants also completed a face-to-face questionnaire survey, including the Hospital Anxiety and Depression Scale, Life Event Stress (LES), and general information.
Serum tumour necrosis factor-α, interleukin- (IL-) 6, IL-8, and IL-10 levels were measured.
The 89 enrolled patients with IBS and 13 healthy controls had no differences in baseline characteristics.
The prevalence of SIBO in patients with IBS was higher than that in healthy controls (39% versus 8%, resp.; p = 0.026 ).
Patients with IBS had higher anxiety, depression, and LES scores, but anxiety, depression, and LES scores were similar between the SIBO-positive and SIBO-negative groups.
Psychological disorders were not associated with SIBO in patients with IBS.
The serum IL-10 level was significantly lower in SIBO-positive than SIBO-negative patients with IBS.
American Psychological Association (APA)
Chu, Hua& Fox, Mark& Zheng, Xia& Deng, Yanyong& Long, Yanqin& Huang, Zhihui…[et al.]. 2016. Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104653
Modern Language Association (MLA)
Chu, Hua…[et al.]. Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104653
American Medical Association (AMA)
Chu, Hua& Fox, Mark& Zheng, Xia& Deng, Yanyong& Long, Yanqin& Huang, Zhihui…[et al.]. Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome: Clinical Characteristics, Psychological Factors, and Peripheral Cytokines. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104653