Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro
Joint Authors
Xiu, Dianhui
Liu, Lin
Qiao, Fengli
Yang, Haishan
Cui, Lu
Liu, Guifeng
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells.
Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3).
And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells.
The upregulated Anxa 2 promoted the proliferation, migration, and invasion of Caco-2 cells in vitro.
Moreover, the STAT3 knockdown also repressed the proliferation, migration, and invasion of Caco-2 cells.
In conclusion, the overexpressed Annexin A2 regulated the proliferation, invasion, and migration in CRC cells in an association with STAT3.
American Psychological Association (APA)
Xiu, Dianhui& Liu, Lin& Qiao, Fengli& Yang, Haishan& Cui, Lu& Liu, Guifeng. 2016. Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104660
Modern Language Association (MLA)
Xiu, Dianhui…[et al.]. Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1104660
American Medical Association (AMA)
Xiu, Dianhui& Liu, Lin& Qiao, Fengli& Yang, Haishan& Cui, Lu& Liu, Guifeng. Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104660
