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Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis
Joint Authors
Guo, Xiaorong
Li, Zhaoshen
Zhan, Xian-Bao
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Researchers have evaluated various molecular tests for improving the differential diagnosis of cystic lesions of the pancreas.
Methods.
Six electronic databases were searched for articles on molecular tests for the diagnosis of pancreatic cysts.
Measures of accuracy were extracted from selected articles and pooled by the random-effects model.
Summary receiver operating characteristic curves were used to analyze the overall accuracy of the molecular tests.
Pooled sensitivity and specificity values [95% confidence intervals] are reported.
Results.
The systematic review included eight studies of 428 patients in total.
We determined the sensitivities and specificities of tests for KRAS mutations (0.47 [0.39–0.54], 0.98 [0.93–0.99]) and loss of heterozygosity (0.63 [0.54–0.71], 0.76 [0.63–0.87]) for distinguishing mucinous from nonmucinous cysts, as well as the sensitivities and specificities of tests for KRAS mutations (0.59 [0.46–0.71], 0.78 [0.71–0.85]) and loss of heterozygosity (0.89 [0.78–0.96], 0.69 [0.60–0.76]) for differentiating malignant from benign cysts.
Conclusion.
Tests of KRAS mutations could confirm but not exclude a diagnosis of a mucinous or malignant pancreatic cyst.
American Psychological Association (APA)
Guo, Xiaorong& Zhan, Xian-Bao& Li, Zhaoshen. 2015. Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104662
Modern Language Association (MLA)
Guo, Xiaorong…[et al.]. Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104662
American Medical Association (AMA)
Guo, Xiaorong& Zhan, Xian-Bao& Li, Zhaoshen. Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104662