Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model
Joint Authors
Vallejo-Flores, Gabriela
Arévalo-Romero, Haruki
Meza, Isaura
Fuentes-Pananá, Ezequiel M.
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Gastric cancer is the third cause of cancer death worldwide and infection by Helicobacter pylori (H.
pylori) is considered the most important risk factor, mainly by the activity of its virulence factor CagA.
H.
pylori/CagA-induced chronic inflammation triggers a series of gastric lesions of increased severity, starting with gastritis and ending with cancer.
IL-1β has been associated with tumor development and invasiveness in different types of cancer, including gastric cancer.
Currently, it is not clear if there is an association between CagA and IL-1β at a cellular level.
In this study, we analyzed the effects of IL-1β and CagA on MCF-10A nontransformed cells.
We found evidence that both CagA and IL-1β trigger the initiation of the epithelial-to-mesenchymal transition characterized by β-catenin nuclear translocation, increased expression of Snail1 and ZEB1, downregulation of CDH1, and morphological changes during MCF-10A acini formation.
However, only CagA induced MMP9 activity and cell invasion.
Our data support that IL-1β and CagA target the β-catenin pathway, with CagA leading to acquisition of a stage related to aggressive tumors.
American Psychological Association (APA)
Arévalo-Romero, Haruki& Meza, Isaura& Vallejo-Flores, Gabriela& Fuentes-Pananá, Ezequiel M.. 2016. Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104698
Modern Language Association (MLA)
Arévalo-Romero, Haruki…[et al.]. Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1104698
American Medical Association (AMA)
Arévalo-Romero, Haruki& Meza, Isaura& Vallejo-Flores, Gabriela& Fuentes-Pananá, Ezequiel M.. Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104698